So we have learned from past trials that Nicotine, Naltrexone, and some Steroids will recover some of Michele's lost functions. Cannibinoids have a similar effect. I am looking into some studies in "molecular mimickry" as it relates to gut bacteria and it looks like there is a very high possibility that some gut bacteria are triggering the chronic hyper-inflammatory situation that exacerbate's Michele's MS. Her constant battle with low grade fever, the periodic rash on the upper left of her chest and back, and that certain anti-inflammatory drugs seem to help...
I will update this blog again when we start on a course of intense antibiotic therapy to eliminate the bad, then re-seeding of the gut with transplanted colonies from a healthy donor.
So to recap on past trial with Naltrexone - yes there was a temporary benefit - but it had the unbearable side effect of night time psychosis, and I was happy that Michele was not able to walk or get herself out of bed to cause me harm.
Nicotine - helped for short bursts to recover arm movement, but side effects of stomach upset and getting amped up on nicotine made this a temporary solution.
Cannibinoids/Medical Marijuana - is the only current solution to the trigeminal neuralgia that Michele has now, replacing the doctor prescribed Vicodin and Lorazepam that suppress her already labored breathing. Looking for Mary Jane that has less of a high while still relieving the spasticity and intense nerve pain.
Michele is down to one barely working hand - her right hand, and has difficulty breathing, no leg use and still has monthly seizure clusters.
Will post updates as I have time....
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